Gates S, Huang T, Cheney F W
Arch Surg. 1983 Nov;118(11):1262-5. doi: 10.1001/archsurg.1983.01390110020005.
We studied the effects of methylprednisolone sodium succinate on the pulmonary function of unanesthetized dogs for four days after aspiration of 1.5 to 2.0 mL/kg of 0.1N hydrochloric acid. Methylprednisolone sodium succinate (30 mg/kg) was administered to nine dogs at 2, 8, and 24 hours after acid aspiration. Nine animals were untreated after aspiration and served as controls. Acid aspiration caused significant increases in venous admixture and reductions in Pao2 in both groups of animals. These changes persisted for 96 hours after aspiration. There were no differences in cardiac output, venous admixture, and blood gas values between treated and untreated animals at any time. At death there were no differences between groups in amounts of lung water or histologic characteristics. We concluded that methylprednisolone administered after hydrochloric acid aspiration does not affect resolution of the injury.
我们研究了琥珀酸甲泼尼龙对吸入1.5至2.0 mL/kg 0.1N盐酸的未麻醉犬在四天内肺功能的影响。在酸吸入后2、8和24小时，给9只犬给予琥珀酸甲泼尼龙（30 mg/kg）。9只动物在吸入酸后未接受治疗，作为对照。酸吸入导致两组动物的静脉混合显著增加和动脉血氧分压降低。这些变化在吸入后持续96小时。在任何时候，治疗组和未治疗组动物的心输出量、静脉混合和血气值均无差异。死亡时，两组在肺水量或组织学特征方面没有差异。我们得出结论，盐酸吸入后给予甲泼尼龙不影响损伤的恢复。
