Schwertschlag U, Hackenthal E
Clin Exp Pharmacol Physiol. 1983 Sep-Oct;10(5):605-8. doi: 10.1111/j.1440-1681.1983.tb00229.x.
The influence of trifluoperazine (TFP) treatment on angiotensin II-induced inhibition of renin release from the rat isolated perfused kidney was examined. Angiotensin II, 1 mumol/l, in the presence of 1 mmol/l calcium, reduced basal renin secretion by 70%. When calcium was omitted from the perfusion medium, inhibition of renin release no longer occurred. Pretreatment of the rat isolated perfused kidney with the calmodulin inhibitor trifluoperazine (TFP), 10 mumol/l for 6 min, interfered with the inhibitory action of angiotensin II on renin release as well as angiotensin II-induced renal vasoconstriction. Our data suggest a role for calmodulin in mediating the effects of angiotensin II on both renin release and renal vascular resistance.
研究了三氟拉嗪（TFP）处理对血管紧张素II诱导的大鼠离体灌注肾脏肾素释放抑制作用的影响。在存在1 mmol/L钙的情况下，1 μmol/L的血管紧张素II使基础肾素分泌减少了70%。当灌注培养基中不含钙时，肾素释放的抑制作用不再发生。用10 μmol/L的钙调蛋白抑制剂三氟拉嗪（TFP）对大鼠离体灌注肾脏进行预处理6分钟，会干扰血管紧张素II对肾素释放的抑制作用以及血管紧张素II诱导的肾血管收缩。我们的数据表明钙调蛋白在介导血管紧张素II对肾素释放和肾血管阻力的作用中发挥作用。
