Rath W, Meyer D, Hildebrandt J, Hilgers R, Kuhn W
Contraception. 1983 Sep;28(3):209-22. doi: 10.1016/0010-7824(83)90062-8.
In a randomized, double-blind study, 30 healthy, nulliparous women of similar gestational age were given intracervical applications of 0.5mg PGE2, 0.05mg Sulprostone or 0.1mg Sulprostone gel in order to soften the cervix prior to curettage for first trimester termination of pregnancy. The preparations were administered 8 hours before curettage. The number of complete and incomplete abortions, ease of passage through the cervical canal, as measured by a tonometer before and 8 hours after the administration of prostaglandin, the degree of pain experienced and the quantity of analgesics required, plus the frequency of systemic side effects were all always assessed by one trialist. With regard to the rate of abortion and cervical softening, the administration of 0.1mg Sulprostone gel proved the most effective method. However, in comparison with the others, it also caused the greatest degree of pain and necessitated the greatest use of analgesics. The softening effect of the prostaglandin E2 gel was significantly less and in this group there were two cases of cervical lesion due to tenaculum laceration. The intracervical application of 0.05mg Sulprostone gel is to be recommended for pre-operative ripening of the cervix before termination of pregnancy in the first trimester, as it effectively dilates the cervix and does not cause systemic side effects or pain in the lower abdomen, enough to make treatment necessary.
在一项随机双盲研究中，30名孕周相似、健康未育的女性在妊娠早期行刮宫术终止妊娠前，宫颈内给予0.5mg前列腺素E2、0.05mg磺前列酮或0.1mg磺前列酮凝胶以软化宫颈。制剂在刮宫术前8小时给药。完全流产和不完全流产的数量、通过宫颈管的难易程度（通过给药前及给药8小时后用张力计测量）、经历的疼痛程度和所需镇痛药的量，以及全身副作用的发生率均由一名试验者评估。关于流产率和宫颈软化情况，0.1mg磺前列酮凝胶给药被证明是最有效的方法。然而，与其他方法相比，它也引起了最大程度的疼痛，且需要最多的镇痛药使用量。前列腺素E2凝胶的软化效果明显较差，该组有2例因宫颈钳撕裂导致宫颈损伤。对于妊娠早期终止妊娠前宫颈的术前成熟，推荐宫颈内应用0.05mg磺前列酮凝胶，因为它能有效扩张宫颈，且不会引起全身副作用或下腹部疼痛而需要进行治疗。
