Applications of bioreactors in medicine.

The use of immobilized enzymes, antibodies or reactive proteins was recently considered as a promising approach for detoxification purposes. The appropriate solutions of some specific problems were described and discussed. An hollow fiber haemodialyzer with a membrane surface area of 0.6 m2 was used as standard support for L-asparaginase immobilization. Hemoperfusion columns based on modified agarose beads were also manufactured for the immobilization of antiphenobarbital antibodies.