Verdy M, Bolte E, Verdy I
Int J Clin Pharmacol Ther Toxicol. 1983 Oct;21(10):487-8.
In the intravenous glucose tolerance test (seven subjects) plasma glucose was not modified, but the insulin levels were lower 2 min after cimetidine was given. Cimetidine modified the oral glucose tolerance test in 13 subjects by increasing the glucose values after 60 min. Insulin levels at that time were also significantly higher. These findings support the hypothesis that cimetidine, an H2 antagonist, could alter glucose handling through its effect on histaminic fibers of the islets of Langerhans.
在静脉葡萄糖耐量试验（7名受试者）中，血浆葡萄糖未发生改变，但给予西咪替丁后2分钟胰岛素水平降低。西咪替丁使13名受试者的口服葡萄糖耐量试验发生改变，60分钟后血糖值升高。此时胰岛素水平也显著更高。这些发现支持这样的假说，即H2拮抗剂西咪替丁可能通过其对胰岛组胺能纤维的作用来改变葡萄糖代谢。
