Sostman H D, Zoghbi S S, Smith G J, Carbo P, Neumann R D, Gottschalk A, Greenspan R H
Invest Radiol. 1983 Sep-Oct;18(5):425-35. doi: 10.1097/00004424-198309000-00005.
Kinetics and magnitudes of changes in Indium-labeled platelet biodistribution were studied in dogs given E. coli endotoxin. Marked, reversible, dose-dependent shifts of platelets from blood to lung and apparently irreversible shifts to liver were demonstrated. These were contemporaneous with alterations in blood gases and in pulmonary and systemic hemodynamics. Morphologic studies revealed atelectasis, sequestration of leukocytes and platelets in the lungs, and mild interstitial pulmonary edema. This study provides in vivo quantification of labeled platelet response to a specific stimulus, and illustrates a method that could be applied to more extensive study of blood element participation in acute lung injury.
在给予大肠杆菌内毒素的犬中研究了铟标记血小板生物分布变化的动力学和幅度。结果表明，血小板从血液向肺有明显的、可逆的、剂量依赖性转移，而向肝脏的转移显然是不可逆的。这些变化与血气以及肺和全身血流动力学的改变同时发生。形态学研究显示有肺不张、肺内白细胞和血小板的扣押，以及轻度间质性肺水肿。本研究提供了体内对标记血小板对特定刺激反应的定量，并阐明了一种可应用于更广泛研究血液成分参与急性肺损伤的方法。
