Lisak R P, Brown M J, Summer A J
Ital J Neurol Sci. 1983 Sep;4(3):265-72. doi: 10.1007/BF02043478.
The Guillain-Barré Syndrome (GBS) is generally considered to be a cell-mediated immunopathologic disease of the peripheral nervous system (PNS), although the evidence for this is indirect. Both in vitro and in vivo studies of sera from experimental animals with autoimmune demyelinating neuropathies suggest that serum factors, including antibodies to PNS myelin and/or Schwann cells, may be important in the pathogenesis of some of these disorders. More recently, similar in vitro and in vivo techniques, including the production of demyelination following intraneural injection in the rat have been employed to study sera from patients with GBS. The results of these studies demonstrate the presence of factor(s), as yet not fully characterized, that may be important in mediating demyelination. Moreover, in some patients with chronic or relapsing demyelinative inflammatory neuropathies and monoclonal gammopathy, there is evidence of antimyelin antibodies to PNS myelin. Further studies of serum from patients with acute GBS and these other neuropathies may clarify the role of serum factors in acquired inflammatory diseases of the PNS.
格林-巴利综合征（GBS）通常被认为是一种外周神经系统（PNS）的细胞介导免疫病理疾病，尽管支持这一观点的证据是间接的。对患有自身免疫性脱髓鞘神经病的实验动物血清进行的体外和体内研究均表明，血清因子，包括针对PNS髓鞘和/或施万细胞的抗体，可能在其中一些疾病的发病机制中起重要作用。最近，类似的体外和体内技术，包括在大鼠神经内注射后产生脱髓鞘的技术，已被用于研究GBS患者的血清。这些研究结果表明存在尚未完全表征的因子，这些因子可能在介导脱髓鞘过程中起重要作用。此外，在一些患有慢性或复发性脱髓鞘性炎性神经病和单克隆丙种球蛋白病的患者中，有针对PNS髓鞘的抗髓鞘抗体的证据。对急性GBS患者和其他这些神经病患者的血清进行进一步研究，可能会阐明血清因子在PNS获得性炎性疾病中的作用。
