多种青霉素在肠杆菌科细菌中诱导头孢菌素酶产生的情况

Induction of cephalosporinase production by various penicillins in enterobacteriaceae.

作者信息

Minami S, Matsubara N, Yotsuji A, Araki H, Watanabe Y, Yasuda T, Saikawa I, Mitsuhashi S

出版信息

J Antibiot (Tokyo). 1983 Oct;36(10):1387-95. doi: 10.7164/antibiotics.36.1387.

DOI:10.7164/antibiotics.36.1387

Abstract

The inducer activity of seven penicillins for cephalosporinase (CSase) production and their antibacterial activity against CSase-producing strains were studied using clinical isolates of Proteus morganii, P. rettgeri, P. vulgaris, Enterobacter cloacae, and Serratia marcescens. Piperacillin, apalcillin, and methicillin showed rather low inducer activity for CSase production in all strains tested. On the other hand, ampicillin, carbenicillin, and sulbenicillin showed high inducer activity for CSase production. Piperacillin, apalcillin, and ampicillin were less stable to CSases than were carbenicillin, sulbenicillin, and methicillin, but much more stable than benzylpenicillin. In the growing culture of CSase-producing strains, piperacillin and apalcillin were rather stable. Against CSase-producing strains, piperacillin and apalcillin were more active than other penicillins tested.

摘要

使用摩根氏变形杆菌、雷氏普罗威登斯菌、普通变形杆菌、阴沟肠杆菌和粘质沙雷氏菌的临床分离株，研究了七种青霉素对头孢菌素酶（CSase）产生的诱导活性及其对产CSase菌株的抗菌活性。哌拉西林、阿帕西林和甲氧西林对所有测试菌株中CSase产生的诱导活性相当低。另一方面，氨苄西林、羧苄西林和磺苄西林对CSase产生具有高诱导活性。与羧苄西林、磺苄西林和甲氧西林相比，哌拉西林、阿帕西林和氨苄西林对CSases的稳定性较差，但比苄青霉素稳定得多。在产CSase菌株的生长培养物中，哌拉西林和阿帕西林相当稳定。对于产CSase菌株，哌拉西林和阿帕西林比其他测试青霉素更具活性。