多种β-内酰胺类抗生素对阴沟肠杆菌β-内酰胺酶的诱导作用。
Induction of beta-lactamase by various beta-lactam antibiotics in Enterobacter cloacae.
作者信息
Minami S, Yotsuji A, Inoue M, Mitsuhashi S
出版信息
Antimicrob Agents Chemother. 1980 Sep;18(3):382-5. doi: 10.1128/AAC.18.3.382.
Abstract
The induction of beta-lactamase in Enterobacter cloacae GN5797 was studied by using 23 beta-lactam antiobiotics, including newly introduced drugs, as inducers. the beta-lactam antibiotics can be classified into three groups on the basis of their inducer activity. Among the tested cephalosporins, cephamycin derivatives such as cefoxitin, cefmetazole, and YM09330 had high inducer activity even at low drug concentrations. On the other hand, cefoperazone, cefsulodin, piperacillin, and apalcillin showed low inducer activity when compared with the other cephalosporins.
摘要
利用23种β-内酰胺类抗生素（包括新上市药物）作为诱导剂，研究了阴沟肠杆菌GN5797中β-内酰胺酶的诱导情况。根据其诱导活性，β-内酰胺类抗生素可分为三组。在所测试的头孢菌素中，头孢西丁、头孢美唑和YM09330等头孢霉素衍生物即使在低药物浓度下也具有高诱导活性。另一方面，与其他头孢菌素相比，头孢哌酮、头孢磺啶、哌拉西林和阿帕西林的诱导活性较低。
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