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在多西拉敏中毒时,阿片类药物和美沙酮的EMIT检测出现假阳性结果。

False-positive EMIT indication of opiates and methadone in a doxylamine intoxication.

作者信息

Hausmann E, Kohl B, von Boehmer H, Wellhöner H H

出版信息

J Clin Chem Clin Biochem. 1983 Oct;21(10):599-600.

PMID:6358402
Abstract

The EMIT-dau for methadone and the EMIT-ST for opiates (both EMITs from Syva-Merck) gave false-positive results when applied to urine samples of a patient suffering from a moderate doxylamine monointoxication. The error was not detected in routine TLC. Gas chromatography and mass spectrometry unequivocally indicated the presence in urine and plasma of doxylamine and its metabolites and the definite absence of methadone. Opiates could not be detected with the Abuscreen RIA (Roche), which is a more sensitive method than EMIT-ST.

摘要

将美沙酮的EMIT-dau和阿片类药物的EMIT-ST(两者均为Syva-Merck公司的EMIT产品)应用于一名中度多西拉敏单一中毒患者的尿液样本时,得出了假阳性结果。在常规薄层色谱法中未检测到该误差。气相色谱法和质谱法明确显示尿液和血浆中存在多西拉敏及其代谢物,且确定不存在美沙酮。使用比EMIT-ST更灵敏的阿片类药物检测试剂盒(罗氏公司)无法检测到阿片类药物。

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False-positive EMIT indication of opiates and methadone in a doxylamine intoxication.在多西拉敏中毒时,阿片类药物和美沙酮的EMIT检测出现假阳性结果。
J Clin Chem Clin Biochem. 1983 Oct;21(10):599-600.
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引用本文的文献

1
Doxylamine toxicity: seizure, rhabdomyolysis and false positive urine drug screen for methadone.多西拉敏中毒:癫痫发作、横纹肌溶解以及美沙酮尿液药物筛查假阳性。
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.09.2008.0879. Epub 2009 Mar 17.