Megamodulin, a cation binding protein from Escherichia coli and its effect on bacterial RNA polymerase.

The versatile multication binding protein, otherwise known as the stimulatory protein kinase modulator (PKMs) or megamodulin has been isolated from Escherichia coli and it has been found to stimulate E. coli RNA polymerase holoenzyme. It has been hypothesized that megamodulin may regulate RNA polymerase activity by blocking the pausing mechanism and/or increased chain elongation activity during the process of transcription, and also may play an important role in protein synthesis.