Sunshine A, Laska E M, Olson N Z, Colon A, Gonzalez L, Tirado S
Pharmacotherapy. 1983 Sep-Oct;3(5):299-303. doi: 10.1002/j.1875-9114.1983.tb03281.x.
Our purpose was to evaluate the analgesic efficacy and safety of single oral doses of propiram fumarate 50 mg, codeine sulfate 60 mg and placebo in the relief of moderate to severe postoperative pain. One hundred and twenty patients completed a randomized, double-blind, single-dose, stratified, parallel-groups trial and were observed for either 4 or 6 hours. Based upon each of the summary efficacy measures--SPID, % SPID and TOTAL--propiram and codeine were approximately equally effective and both were statistically superior to placebo. Propiram was significantly more effective than codeine at hour 5 for Pain Intensity Difference. Two adverse effects were attributed to propiram. Propiram fumarate 50 mg is an effective oral analgesic similar to codeine sulfate 60 mg, with the possibility of a longer duration of action.
我们的目的是评估单次口服50毫克富马酸丙帕他莫、60毫克硫酸可待因和安慰剂缓解中重度术后疼痛的镇痛效果及安全性。120名患者完成了一项随机、双盲、单剂量、分层、平行组试验，并观察4或6小时。基于每项综合疗效指标——SPID、%SPID和TOTAL——丙帕他莫和可待因的疗效大致相同，且在统计学上均优于安慰剂。在疼痛强度差异方面，丙帕他莫在第5小时比可待因显著更有效。有两种不良反应归因于丙帕他莫。50毫克富马酸丙帕他莫是一种有效的口服镇痛药，与60毫克硫酸可待因相似，且作用持续时间可能更长。
