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[使用半胱胺和8-溴咖啡因对全身X射线辐射后大鼠肝细胞DNA损伤的修饰]

[Modification of DNA damage in rat hepatocytes following whole-body roentgen radiation using cysteamine and 8-bromocaffeine].

作者信息

Smirnova I S, Suslov A V, Noskin L A

出版信息

Radiobiologiia. 1983 Sep-Oct;23(5):653-6.

PMID:6359245
Abstract

Using the elastoviscosimetric method it was shown that the level of residual DNA double-strand breaks in rat hepatocytes depended on conditions of total-body X-irradiation: it increased in the presence of a sensitizer, 8-bromocaffeine and decreased in the presence of a protector, cysteamine. This correlation confirms a major role of fixed DNA double-strand breaks in the formation of a lethal effect in a cell.

摘要

采用弹性粘滞测定法表明，大鼠肝细胞中残留DNA双链断裂的水平取决于全身X射线照射的条件：在敏化剂8-溴咖啡因存在时增加，而在保护剂半胱胺存在时降低。这种相关性证实了固定的DNA双链断裂在细胞致死效应形成中的主要作用。

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