Melamed I, Romem Y, Shimoni T, Perek Y, Dolev E
Scand J Infect Dis. 1983;15(3):303-6. doi: 10.3109/inf.1983.15.issue-3.11.
16 reserve soldiers received an overdose of tetanus toxoid vaccine (5 ml instead of 0.5 ml) in error. We assessed the incidence and severity of adverse reactions and determined tetanus antibody titer immediately and after 5 days, 1 month and 1 year, and compared it with the titers in a control group of 20 soldiers. The incidence and severity of reactions was significantly higher in the overdose group. The mean tetanus antibody titer rose to similar levels in both groups after 1 month (153.75 +/- 82.5 IU/ml and 62.02 +/- 42.15 IU/ml respectively) but decreased sharply after 1 year in the overdose group.
16名预备役军人误接种了过量破伤风类毒素疫苗（5毫升而非0.5毫升）。我们评估了不良反应的发生率和严重程度，并在接种后即刻、5天、1个月和1年时测定破伤风抗体滴度，同时与20名军人组成的对照组的滴度进行比较。过量接种组的反应发生率和严重程度显著更高。1个月后两组的平均破伤风抗体滴度升至相似水平（分别为153.75±82.5国际单位/毫升和62.02±42.15国际单位/毫升），但过量接种组在1年后抗体滴度急剧下降。
