Mäkelä P H, Karma P, Sipilä M, Pukander J, Leinonen M
Scand J Infect Dis Suppl. 1983;39:34-8.
The prerequisites for preventing a considerable proportion of acute otitis media (AOME) of children are theoretically good--pneumococcal types/groups present in the available 14-valent pneumococcal capsular polysaccharide vaccine are the most common bacteria in AOME, and a good serum antibody response is followed by type-specific protection from infection. However, the four most common types/groups (= 2/3 of all pneumococci in AOME) have very poor immunizing capacity in infants, and therefore the vaccine offers little protection from AOME for children under the age of 2 years. This information should help towards an improved new vaccine for AOME.
预防相当一部分儿童急性中耳炎（AOME）的前提条件理论上是良好的——市售14价肺炎球菌荚膜多糖疫苗中包含的肺炎球菌类型/菌群是AOME中最常见的细菌，良好的血清抗体反应之后会产生针对特定类型感染的保护作用。然而，四种最常见的类型/菌群（占AOME中所有肺炎球菌的2/3）在婴儿中的免疫能力非常差，因此该疫苗对2岁以下儿童预防AOME几乎没有作用。这一信息应有助于研发出更好的AOME新型疫苗。
