Shinderite V S, Sabaliauskas I Iu, Iasaĭtis A A
Tsitologiia. 1983 Sep;25(9):1059-65.
Using light and electron microscopy, as well as stereological analysis, a study was made of structural changes in mitochondria of cultured L-cells acted upon with 1 mM cyanide. After 23 hours of incubation, in cells cultured in the presence of cyanide the volume density of mitochondria, the volume of the average mitochondrion and the surface area of its membranes increased nearly twice as much. Concurrently, the number of mitochondria decrease also practically two-fold without any reliable changes in the surface area of membranes per unit of mitochondrion volume. A shorter (7 hours) incubation of L-cells in the presence of cyanide results in a decreased volume density of mitochondria in the cytoplasm, decreased volume of the average mitochondrion, without any significant changes in other above mentioned parameters. It is supposed that the changes in mitochondria under a prolonged cyanide treatment of cells are conditioned by the fusion of mitochondria as well as by a compensatory increase in the total surface of mitochondrial membranes.
运用光学显微镜、电子显微镜以及体视学分析方法，对用1毫摩尔氰化物处理的培养L细胞线粒体的结构变化进行了研究。孵育23小时后，在氰化物存在下培养的细胞中，线粒体的体积密度、平均线粒体体积及其膜表面积增加了近两倍。同时，线粒体数量实际上也减少了近两倍，而单位线粒体体积的膜表面积没有任何可靠变化。在氰化物存在下对L细胞进行较短时间（7小时）的孵育，会导致细胞质中线粒体的体积密度降低，平均线粒体体积减小，而上述其他参数没有任何显著变化。据推测，细胞在长时间氰化物处理下线粒体的变化是由线粒体融合以及线粒体膜总表面积的代偿性增加所导致的。
