Ratzmann K P, Jutzi E, Albrecht G
Z Exp Chir Transplant Kunstliche Organe. 1983;16(5):270-6.
The clinical importance of different constants used in the algorithm of a glucose-controlled insulin infusion system (Biostator) with respect to insulin requirement was studied in 9 insulin-dependent juvenile-onset type diabetics. After normalizing the fasting blood glucose level (around 4.5 mmol/l), 3 consecutive glucose infusions (12 mg . kg-1 . min-1) followed by a 1 h post-infusion period were carried out in all individuals. The blood glucose was controlled by the Biostator using three sets of constants: A (KR = 160, KF = 50, QI = 30, RI = 12), B (KR = 70, KF = 50, QI = 40, RI = 12) and C (KR = 20, KF = 50, QI = 50, RI = 20). The algorithm constants were changed in an arbitrary order before the start of each glucose infusion in the same patient. Mean blood glucose profiles were comparable whereas the mean total insulin dose infused by the Biostator amounted to 13 +/- 1.3 U/h, 7.8 +/- 1.2 U/h and 7.0 +/- 1.0 U/h when sets A, B and C were applied (A versus B and C p less than 0.01). The higher insulin amount during control of set A was mainly due to a high insulin infusion during the first 20 min. In summary, the results emphasize the clinical importance of appropriate algorithm constants of a glucose-controlled insulin infusion system for evaluation of the insulin requirement in insulin-dependent diabetics.
在9名胰岛素依赖型青少年发病型糖尿病患者中，研究了葡萄糖控制胰岛素输注系统（Biostator）算法中使用的不同常数对胰岛素需求的临床重要性。在将空腹血糖水平标准化（约4.5 mmol/l）后，对所有个体进行了3次连续的葡萄糖输注（12 mg·kg-1·min-1），随后是1小时的输注后观察期。使用Biostator通过三组常数控制血糖：A组（KR = 160，KF = 50，QI = 30，RI = 12）、B组（KR = 70，KF = 50，QI = 40，RI = 12）和C组（KR = 20，KF = 50，QI = 50，RI = 20）。在同一患者每次葡萄糖输注开始前，以任意顺序改变算法常数。平均血糖曲线具有可比性，而当应用A组、B组和C组时，Biostator输注的平均总胰岛素剂量分别为13±1.3 U/h、7.8±1.2 U/h和7.0±1.0 U/h（A组与B组和C组相比，p<0.01）。A组控制期间较高的胰岛素用量主要是由于最初20分钟内胰岛素输注量较高。总之，结果强调了葡萄糖控制胰岛素输注系统的适当算法常数对评估胰岛素依赖型糖尿病患者胰岛素需求的临床重要性。
