Saúl A, Novales J
Acta Leprol. 1983 Jul-Sep;1(3):115-32.
The Lucio-Latapí's leprosy or diffuse lepromatous leprosy is a clinical variety of lepromatous leprosy first described by Lucio and Alvarado in 1852 and reidentified by Latapí in 1936. It is frequent in Mexico (23%) and in Costa Rica and very rare in other countries. It is characterized by a diffuse infiltration of all the skin which never is transformed into nodule, by a complete alopecia of eyebrows and eyelashes and body hair, by anhydrotic and dysesthesic zones of the skin and by a peculiar type of lepra reaction named Lucio's phenomenon or necrotic erythema which is a vascularitis of vessels especially of the dermohypodermic union and of the hypodermis. Clinically this vascularitis is represented by well-shaped erythematous spots, later becoming necrotic with scabs, ulcerations and scars. Three points of confusion are stressed: the differences between nodules and nudosities, Lucio's leprosy and Lucio's phenomenon and necrotic erythema and necrotic erythema nodosum leprosum. The differences between the pure and primitive form of Lucio's leprosy and the secondary one is also discussed such as the laboratory findings, histopathological data, pronostic and treatment. Lucio's leprosy is considered the most anergic one of the all immunological spectrum of leprosy.
卢西奥 - 拉塔皮麻风病或弥漫性瘤型麻风病是瘤型麻风病的一种临床类型，1852年由卢西奥和阿尔瓦拉多首次描述，1936年由拉塔皮重新确认。它在墨西哥很常见（23%），在哥斯达黎加也较为常见，而在其他国家非常罕见。其特征为全身皮肤弥漫性浸润且从不形成结节，眉毛、睫毛及体毛完全脱落，皮肤出现无汗和感觉障碍区，以及一种特殊类型的麻风反应，即卢西奥现象或坏死性红斑，这是一种血管炎，尤其累及真皮与皮下组织交界处及皮下组织的血管。临床上，这种血管炎表现为形态规整的红斑，随后发展为坏死，伴有结痂、溃疡和瘢痕。文中强调了三点容易混淆之处：结节与瘤样病变的区别、卢西奥麻风病与卢西奥现象的区别以及坏死性红斑与麻风结节性红斑的区别。还讨论了卢西奥麻风病的纯原始形式与继发形式之间的差异，如实验室检查结果、组织病理学数据、预后及治疗等。卢西奥麻风病被认为是麻风病所有免疫类型中最无反应性的一种。
