解热镇痛治疗史。

History of antipyretic analgesic therapy.

作者信息

Haas H

出版信息

Am J Med. 1983 Nov 14;75(5A):1-3. doi: 10.1016/0002-9343(83)90225-5.

Abstract

The use of naturally occurring plant materials for the relief of pain dates back to 3,000 B.C., although rapid advances in antipyretic analgesic therapy have been made more recently. Salicylic acid was synthesized in 1860, and the pyrazolone group, first represented by antipyrine, in 1883. Phenacetin was developed in 1886. Acetaminophen has been in use since the 1890s.

摘要

使用天然植物材料缓解疼痛的历史可以追溯到公元前3000年，不过，解热镇痛药疗法在近代取得了快速进展。1860年合成了水杨酸，1883年出现了以安替比林为首个代表药物的吡唑酮类药物。1886年研发出了非那西丁。对乙酰氨基酚自19世纪90年代起开始使用。