Tyshchenko A F, Bylinkina E S, Sobachkina I S, Orekhova V M, Kobzeva V K
Antibiotiki. 1983 Nov;28(11):806-10.
The data on the effect of the aeration and agitation conditions on biosynthesis of oleandomycin in 0.75, 3 and 50 m3 apparatus are presented. The relationship between the biosynthetic parameters, oxygen dissolution rate and specific power consumption for agitation was studied. It was shown that the values of the specific power consumption for agitation were not acceptable for scaling up the process of oleandomycin biosynthesis.
给出了在0.75立方米、3立方米和50立方米设备中，通气和搅拌条件对竹桃霉素生物合成影响的数据。研究了生物合成参数、氧溶解速率和搅拌比功耗之间的关系。结果表明，搅拌比功耗的值对于竹桃霉素生物合成过程的放大是不可接受的。
