Warner T F, Lloyd R V, Hafez G R, Angevine J M
Cancer. 1984 Jan 15;53(2):254-7. doi: 10.1002/1097-0142(19840115)53:2<254::aid-cncr2820530212>3.0.co;2-o.
Schwann cell differentiation has been proposed in the histogenesis of neurotropic melanoma by light and electron microscopic studies, and melanosomes are rarely, if ever, detected in the spindle cell component of this tumor. S-100 immunoreactivity has previously been demonstrated in Schwann cells of benign neurogenic tumors and most malignant melanomas. The authors report S-100 immunoreactivity in spindle cell elements of neurotropic melanoma. Focal neuron-specific enolase immunoreactivity was also found. These findings, in the absence of melanosomes in tumor cells, support the contention that the spindle cell element of neurotropic melanoma is derived from cells of neural crest origin.
通过光学显微镜和电子显微镜研究，在亲神经性黑色素瘤的组织发生过程中已提出雪旺细胞分化，并且在该肿瘤的梭形细胞成分中极少（如果有的话）检测到黑素小体。先前已在良性神经源性肿瘤和大多数恶性黑色素瘤的雪旺细胞中证实了S-100免疫反应性。作者报告了亲神经性黑色素瘤梭形细胞成分中的S-100免疫反应性。还发现了局灶性神经元特异性烯醇化酶免疫反应性。在肿瘤细胞中不存在黑素小体的情况下，这些发现支持了亲神经性黑色素瘤的梭形细胞成分源自神经嵴起源细胞的论点。
