Dorey P G, King J, Munday K A, Parsons B J, Poat J A
J Physiol. 1983 Nov;344:1-9. doi: 10.1113/jphysiol.1983.sp014919.
A comparison has been made of intestinal fluid absorption between male Okamoto spontaneously hypertensive rats (s.h.r.) and normotensive male Wistar controls. S.h.r. show enhanced fluid absorption both in hypertensive adults and in young s.h.r. before hypertension has developed. Several potential causes for increased fluid transport in s.h.r. were tested using pharmacological antagonists. It is unlikely that enhanced fluid absorption is due to high sympathetic nervous activity, the renin-angiotensin system or is secondary to hypertension. Intestine from s.h.r. have a high short-circuit current indicating a change in ion pump activity. These results are discussed in relation to the possible causes of increased fluid (ion) transport by the intestine of s.h.r.
对雄性冈本自发性高血压大鼠(s.h.r.)和正常血压的雄性Wistar对照大鼠的肠液吸收情况进行了比较。无论是高血压成年大鼠还是高血压发生前的幼年s.h.r.,其肠液吸收均增强。使用药理学拮抗剂对s.h.r.中液体转运增加的几种潜在原因进行了测试。肠液吸收增强不太可能是由于高交感神经活性、肾素-血管紧张素系统或继发于高血压。s.h.r.的肠道具有较高的短路电流,表明离子泵活性发生了变化。结合s.h.r.肠道液体(离子)转运增加的可能原因对这些结果进行了讨论。