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自发性高血压大鼠的肠液吸收

Intestinal fluid absorption in spontaneously hypertensive rats.

作者信息

Dorey P G, King J, Munday K A, Parsons B J, Poat J A

出版信息

J Physiol. 1983 Nov;344:1-9. doi: 10.1113/jphysiol.1983.sp014919.

Abstract

A comparison has been made of intestinal fluid absorption between male Okamoto spontaneously hypertensive rats (s.h.r.) and normotensive male Wistar controls. S.h.r. show enhanced fluid absorption both in hypertensive adults and in young s.h.r. before hypertension has developed. Several potential causes for increased fluid transport in s.h.r. were tested using pharmacological antagonists. It is unlikely that enhanced fluid absorption is due to high sympathetic nervous activity, the renin-angiotensin system or is secondary to hypertension. Intestine from s.h.r. have a high short-circuit current indicating a change in ion pump activity. These results are discussed in relation to the possible causes of increased fluid (ion) transport by the intestine of s.h.r.

摘要

对雄性冈本自发性高血压大鼠(s.h.r.)和正常血压的雄性Wistar对照大鼠的肠液吸收情况进行了比较。无论是高血压成年大鼠还是高血压发生前的幼年s.h.r.,其肠液吸收均增强。使用药理学拮抗剂对s.h.r.中液体转运增加的几种潜在原因进行了测试。肠液吸收增强不太可能是由于高交感神经活性、肾素-血管紧张素系统或继发于高血压。s.h.r.的肠道具有较高的短路电流,表明离子泵活性发生了变化。结合s.h.r.肠道液体(离子)转运增加的可能原因对这些结果进行了讨论。

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本文引用的文献

1
Active transport of sodium as the source of electric current in the short-circuited isolated frog skin.
Acta Physiol Scand. 1951 Aug 25;23(2-3):110-27. doi: 10.1111/j.1748-1716.1951.tb00800.x.
2
QUANTITATIVE ASSAY AND DISAPPEARANCE RATE OF CIRCULATING RENIN.
Am J Physiol. 1964 Jun;206:1361-4. doi: 10.1152/ajplegacy.1964.206.6.1361.
3
Development of a strain of spontaneously hypertensive rats.
Jpn Circ J. 1963 Mar;27:282-93. doi: 10.1253/jcj.27.282.
4
Possible role of chronic excess salt consumption in the pathogenesis of essential hypertension.
Am J Cardiol. 1961 Oct;8:571-5. doi: 10.1016/0002-9149(61)90137-0.
5
Similarities of genetic (spontaneous) hypertension. Man and rat.
Circ Res. 1981 Mar;48(3):309-19. doi: 10.1161/01.res.48.3.309.
6
Increased sodium permeability of erythrocytes in spontaneously hypertensive rats.
Clin Exp Pharmacol Physiol. 1980 Sep-Oct;7(5):527-30. doi: 10.1111/j.1440-1681.1980.tb00104.x.
7
Endogenous norepinephrine release induced by tyramine modulates intestinal ion transport.
Am J Physiol. 1981 Sep;241(3):G264-9. doi: 10.1152/ajpgi.1981.241.3.G264.
9
Intracellular Na+ as a genetic marker of essential hypertension.
Clin Exp Hypertens (1978). 1981;3(4):627-40. doi: 10.3109/10641968109033689.
10
Sodium transport and short-circuit current in rat colon in vivo and the effect of aldosterone.
J Physiol. 1970 Nov;210(4):1021-39. doi: 10.1113/jphysiol.1970.sp009255.

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