自发性高血压大鼠红细胞钠通透性增加。

Increased sodium permeability of erythrocytes in spontaneously hypertensive rats.

Wiley J S, Hutchinson J S, Mendelsohn F A, Doyle A E

Clin Exp Pharmacol Physiol. 1980 Sep-Oct;7(5):527-30. doi: 10.1111/j.1440-1681.1980.tb00104.x.

Abstract

The Na permeability of red cells from spontaneously hypertensive rats (SHR) has been studied. In the Japanese Wister-Kyoto strain, a significant increase of 30% in 22Na influx for male SHR was found compared with normotensive male controls. In contrast the Na influx for genetically hypertensive and normotensive New Zealand rats did not differ. Normotensive Wister-Kyoto rats rendered hypertensive by unilateral renal artery clipping, did not show any difference in Na influx from control animals. 2. These results suggest that the Japanese strain of SHR has a genetically determined increase in erythrocyte Na permeability.

摘要

对自发性高血压大鼠（SHR）红细胞的钠通透性进行了研究。在日本Wister-Kyoto品系中，发现雄性SHR的22Na内流比正常血压雄性对照显著增加30%。相比之下，遗传性高血压和正常血压的新西兰大鼠的钠内流没有差异。通过单侧肾动脉夹闭使正常血压的Wister-Kyoto大鼠血压升高，其钠内流与对照动物没有差异。2. 这些结果表明，日本品系的SHR红细胞钠通透性的增加是由基因决定的。