Vanderweele D A, Van Itallie T B
Physiol Behav. 1983 Oct;31(4):533-7. doi: 10.1016/0031-9384(83)90078-1.
A group of six female, albino rats were maintained on a cafeteria diet of cookies, milk, and elevated-fat (shortening), rat-chow mixture and rat chow while a similar group received only rat chow ad lib for 17 weeks. When the groups differed significantly in mean body weight (obese-387.5 g, controls-287.2 g; p less than 0.001), gastric fistulas were implanted in each animal. After recovery, the rats were adapted to a liquid diet and assessed for sham feeding. Control-fed, normal-body-weight subjects showed substantial sham feeding when ingesting the Vivonex with the fistulas open compared to fistula-closed intake; meal frequency, meal size (apart from the initial meal) and total food intake were significantly increased while the satiety ratios following each meal were significantly decreased. Obese animals showed no significant increased feeding and satiety ratios were unreliably altered; while normal-body-weight controls increased 4-hr food intakes by 93% and halved their mean satiety ratios the obese animals showed an 8% increase in 4-hr food intake and only a 22% decrease in mean satiety ratios. We offer the hypothesis that, when animals are induced to become obese by palatable and varied diets which are then terminated, the anorexia produced is independent of gastrointestinal interactions inasmuch as that anorexia extends to sham feeding.
一组六只雌性白化大鼠被喂食由饼干、牛奶和高脂肪（起酥油）、大鼠饲料混合而成的自助餐式饮食以及大鼠饲料，而另一组相似的大鼠仅随意进食大鼠饲料，持续17周。当两组大鼠的平均体重出现显著差异时（肥胖组-387.5克，对照组-287.2克；p小于0.001），给每只动物植入胃瘘。恢复后，让大鼠适应流食饮食并评估假饲情况。与瘘管闭合时摄入Vivonex相比，喂食对照饲料、体重正常的受试大鼠在瘘管开放时摄入Vivonex时表现出大量假饲；进餐频率、餐量（除第一餐外）和总食物摄入量显著增加，而每餐之后的饱腹感比率显著降低。肥胖动物的进食量没有显著增加，饱腹感比率变化不可靠；体重正常的对照组4小时食物摄入量增加了93%，平均饱腹感比率减半，而肥胖动物4小时食物摄入量仅增加了8%，平均饱腹感比率仅降低了22%。我们提出一个假说，即当动物因美味多样的饮食而变得肥胖，随后停止该饮食时，产生的厌食症与胃肠道相互作用无关，因为这种厌食症会延伸至假饲。
