Tan C M, Im M J, Myers R A, Hoopes J E
Plast Reconstr Surg. 1984 Jan;73(1):27-30. doi: 10.1097/00006534-198401000-00005.
The effects of hyperbaric air and oxygen on skin survival were studied in acute 8 X 8 cm neurovascular island flaps in rats. Skin flaps treated with hyperbaric 8% oxygen (equivalent to room air at standard pressure) exhibited no improvement in skin survival. Skin flaps treated with hyperbaric air (21% oxygen) and hyperbaric 100% oxygen exhibited significant increases in survival.