Kaikai P, Thurnham D I
Trans R Soc Trop Med Hyg. 1983;77(5):680-6. doi: 10.1016/0035-9203(83)90204-3.
Two experiments were done in which rats in various stages of riboflavin deficiency were infected with Plasmodium berghei. Various control groups were included to compare the influence of food restriction on the P. berghei infection with that of riboflavin deficiency, namely, pair-fed (PF), weight-matched (WM) and ad libitum-fed (C-AL) control groups. Riboflavin deficiency depressed maximum parasite counts by comparison with all control groups and the degree of depression was inversely related to the riboflavin status. Survival of animals with P. berghei infection was approximately 10 to 14 days and was not significantly influenced by any of the dietary regimens. Two possible mechanisms by which riboflavin deficiency might influence the growth and multiplication of P. berghei are discussed, namely, a depression of reticulocytosis and an effect on the synthesis of reduced glutathione in the parasite or red blood cell.
进行了两项实验，在实验中，处于不同核黄素缺乏阶段的大鼠感染了伯氏疟原虫。设置了各种对照组，以比较食物限制对伯氏疟原虫感染的影响与核黄素缺乏的影响，即配对喂养（PF）、体重匹配（WM）和自由采食（C-AL）对照组。与所有对照组相比，核黄素缺乏降低了最大寄生虫计数，且降低程度与核黄素状态呈负相关。感染伯氏疟原虫的动物存活时间约为10至14天，且不受任何饮食方案的显著影响。讨论了核黄素缺乏可能影响伯氏疟原虫生长和繁殖的两种可能机制，即网织红细胞增多症的抑制以及对寄生虫或红细胞中还原型谷胱甘肽合成的影响。
