胸腔积液中的癌胚抗原。在恶性间皮瘤中的诊断价值。

Carcinoembryonic antigen in pleural effusions. Diagnostic value in malignant mesothelioma.

作者信息

Faravelli B, D'Amore E, Nosenzo M, Betta P G, Donna A

出版信息

Cancer. 1984 Mar 1;53(5):1194-7. doi: 10.1002/1097-0142(19840301)53:5<1194::aid-cncr2820530528>3.0.co;2-n.

DOI:10.1002/1097-0142(19840301)53:5<1194::aid-cncr2820530528>3.0.co;2-n

Abstract

The usefulness of the determination of carcinoembryonic antigen (CEA) in pleural effusion was assessed as an aid to the diagnosis of malignant mesothelioma. The concentration of CEA was determined by radioimmunoassay (RIA) in pleural fluid of 213 adult patients, of which 140 had malignant pleural disease and 73 had nonmalignant pleural disease. Pleural fluid CEA (PF CEA) was lower than 12 ng/ml in all 15 mesotheliomas. The statistical probability of a mesothelioma associated with PF CEA greater than 15 ng/ml was found to be zero. The CEA assay in pleural effusion proved to be a valuable adjunct to other diagnostic procedures in differentiating the malignant mesothelioma from metastatic serosal spread.

摘要

评估了测定胸腔积液中癌胚抗原（CEA）对恶性间皮瘤诊断的辅助作用。采用放射免疫分析法（RIA）测定了213例成年患者胸腔积液中CEA的浓度，其中140例患有恶性胸膜疾病，73例患有非恶性胸膜疾病。所有15例间皮瘤患者的胸腔积液CEA（PF CEA）均低于12 ng/ml。发现PF CEA大于15 ng/ml的间皮瘤的统计概率为零。胸腔积液CEA检测被证明是区分恶性间皮瘤与转移性浆膜扩散的其他诊断方法的有价值辅助手段。