胸腔积液生化分析的诊断价值。癌胚抗原和β2微球蛋白。

Diagnostic value of biochemical analysis of pleural effusions. Carcinoembryonic antigen and beta 2 microglobulin.

作者信息

Vladutiu A O, Adler R H, Brason F W

出版信息

Am J Clin Pathol. 1979 Feb;71(2):210-4. doi: 10.1093/ajcp/71.2.210.

DOI:10.1093/ajcp/71.2.210

Abstract

Pleural effusions from 105 patients with malignant and nonmalignant diseases were examined for tumor cells, content of CEA, beta2 microglobulin, ceruloplasmin, alpha2 macroglobulin, orosomucoid, lysozyme, and hexosaminidase. Only CEA and beta2 microglobulin determinations were of diagnostic value. CEA concentrations greater than 11 ng/ml were found only in malignant effusions. Beta 2 microglobulin values were increased in pleural effusions due to lymphoma or immune diseases. Measurement of CEA and beta2 microglobulin in addition to the cytologic examination could increase the diagnostic significance of the analysis of pleural effusions.

摘要

对105例患有恶性和非恶性疾病患者的胸腔积液进行了肿瘤细胞、癌胚抗原（CEA）、β2微球蛋白、铜蓝蛋白、α2巨球蛋白、类粘蛋白、溶菌酶和己糖胺酶含量的检测。只有CEA和β2微球蛋白的测定具有诊断价值。CEA浓度大于11 ng/ml仅在恶性胸腔积液中发现。β2微球蛋白值在淋巴瘤或免疫疾病所致的胸腔积液中升高。除了细胞学检查外，检测CEA和β2微球蛋白可提高胸腔积液分析的诊断意义。