Gueux E, Rayssiguier Y
Horm Metab Res. 1983 Dec;15(12):594-7. doi: 10.1055/s-2007-1018801.
Weanling Sherman rats were pair-fed for 8 days on a control or a magnesium deficient diet containing 70.5% sucrose. After a 12-hour fast, the rats were injected intraperitoneally with glucose (250 mg/100 g body weight) and arterial blood was drawn at 0, 15, 30, 60, 90 minutes after injection. Before glucose loading, in magnesium deficient rats, plasma magnesium levels were significantly increased. The plasma triglyceride concentration was significantly higher in magnesium deficient rats compared to controls. After glucose loading, in the control group, the plasma insulin concentrations increased to 67.9 +/- 5.8 microU/ml at 15 minutes and returned to pretreatment levels by 30 minutes; in the magnesium-deficient rats, the plasma insulin levels were significantly lower at 15 minutes 32.9 +/- 5.6 microU/ml (P less than 0.01) and returned more slowly to the pre-challenge level. No significant differences were observed in plasma glucose levels between the two groups of rats.
将断乳的谢尔曼大鼠在含70.5%蔗糖的对照或缺镁饮食条件下配对喂养8天。禁食12小时后，给大鼠腹腔注射葡萄糖（250毫克/100克体重），并在注射后0、15、30、60、90分钟采集动脉血。在葡萄糖负荷前，缺镁大鼠的血浆镁水平显著升高。与对照组相比，缺镁大鼠的血浆甘油三酯浓度显著更高。葡萄糖负荷后，对照组血浆胰岛素浓度在15分钟时升至67.9±5.8微单位/毫升，并在30分钟时恢复到预处理水平；在缺镁大鼠中，血浆胰岛素水平在15分钟时显著较低，为32.9±5.6微单位/毫升（P<0.01），且恢复到攻击前水平的速度更慢。两组大鼠的血浆葡萄糖水平未观察到显著差异。
