Russell P S
Hepatology. 1984 Jan-Feb;4(1 Suppl):76S-78S. doi: 10.1002/hep.1840040720.
Immunological considerations of special interest in liver transplantation are examined. It is concluded that liver transplants between human beings generate typical rejection reactions although they may, overall, be somewhat more mild than those encountered in transplanted kidneys and hearts. This is the case in some animals for reasons which are not yet clear. There is evidence that the transplanted liver can suffer immune attack better than other organs. Whether graft-vs.-host activity is of clinical importance is uncertain. The advent of cyclosporin immunosuppression has improved the outlook for liver recipients but multiple complications of immunosuppression will still occur and demand skillful management.
本文探讨了肝脏移植中特别值得关注的免疫学问题。研究得出结论，人类之间的肝脏移植会引发典型的排斥反应，尽管总体而言，这些反应可能比肾移植和心脏移植中的排斥反应更为轻微。某些动物也存在这种情况，但其原因尚不清楚。有证据表明，移植的肝脏比其他器官更能耐受免疫攻击。移植物抗宿主反应是否具有临床重要性尚不确定。环孢素免疫抑制疗法的出现改善了肝脏移植受者的预后，但免疫抑制的多种并发症仍会发生，需要精湛的管理。
