[Antifungal and antimicrobial activity of beta-ionone and vitamin A derivatives].

The antifungal and antimicrobic activity of some derivatives of beta-ionon and vitamin A was studied. These compounds (citral, pseudo-ionon. beta-ionon aldehyde C14, ketone C18 and its derivatives--4,18-diketone, alcohol C18, semicarbazide ketone C18), as well as vitamin A and its derivatives--retinal, acetate, retinoic acid--differ in composition, structure and substituents of C-atoms in beta-ionon ring and in polyenoic chain. Fusarium solani, Botrytis cenerea and Verticillum dahliae II, race 447 were used as test organisms when studying the antifungal activity. When studying the antimicrobic activity, ketone C18 and alcohol C18 were tested using the museum strains Staphylococcus aureus 209 P, hemolytic Streptococcus pyogenes FF-38, Streptococcus sp. TOM-1606, Micrococcus luteus 2665, as well as the strains Staphylococcus aureus isolated from pyoderma patients. The antifungal activity was determined by inhibition of spore germination, and the antimicrobic activity--by the value of areas of growth inhibition of the test organisms on the agar medium. All the compounds mentioned above possessed the antifungal activity against all the phytopathogenes used. The degree of this activity depends on the composition and structure of both the cyclic part and polyenoic chain. on the number of conjugated unsaturations, substituents and end groups of C-atom. Ketone C18 is the most active one. It inhibits spore germination by 100-94% at concentrations ranging from 0.05 to 0.005% and 24 h exposure, and by 100% at the concentration of 0.1% and 72 h exposure. Alcohol C18 possesses almost the same antifungul activity.(ABSTRACT TRUNCATED AT 250 WORDS)