Buell D N
Semin Oncol. 1983 Sep;10(3):311-21.
Clinical and metabolic features of the trace element selenium and the full spectrum of its animal and human toxicity have been reviewed. The difficulties in coming to an easy understanding of the biologic properties of selenium stem from its multiple forms and complex metabolic and biochemical pathways. It is suggested that chemoprevention trials focus on the efficacy of organic and inorganic prototype forms such as selenomethionine and the selenite ion. While some appreciation of the toxic potential of these two prototype forms can be predicted from existing information, additional formal toxicology will be necessary, particularly for selenomethionine.
本文综述了微量元素硒的临床和代谢特征及其在动物和人类中的全部毒性。难以轻松理解硒生物学特性的原因在于其多种形式以及复杂的代谢和生化途径。建议化学预防试验聚焦于有机和无机原型形式的功效，如硒代蛋氨酸和亚硒酸根离子。虽然根据现有信息可以预测这两种原型形式的潜在毒性，但仍需要进行额外的正式毒理学研究，尤其是针对硒代蛋氨酸。
