Sitzmann G C, Arnold E, Gailer H, Istvan L, Kaloud H, Teubl I
Wien Klin Wochenschr. 1978 Apr 14;90(8):270-4.
The distribution of the phenotypes of the red cell enzymes adenosine deaminase, adenylate kinase, glutamate pyruvate dehydrogenase, 6-phosphogluconate dehydrogenase and phosphoglucomutase was studied in blood samples of 794 West Hungarian subjects and 955 subjects from Franconia in Bavaria. All enzymes were separated on cellulose acetate foil, SEP in starch gel. The method of separation has been described elsewhere. The phenotypes of all enzymes were found to be distributed according to the Hardy-Weinberg law. The calculated gene frequencies were in good agreement with data from the literature, according to the results of other investigations carried out in Germany and the central European region. No significant difference was found between the gene frequencies of these enzyme phenotypes in West Hungary and Franconia, although the PGM2 frequency level was higher in West Hungary than in Franconia.
对794名匈牙利西部受试者和955名巴伐利亚州弗兰肯地区受试者的血样,研究了红细胞酶腺苷脱氨酶、腺苷酸激酶、谷氨酸丙酮酸脱氢酶、6 - 磷酸葡萄糖酸脱氢酶和磷酸葡萄糖变位酶的表型分布。所有酶均在醋酸纤维素薄膜上进行分离,SEP在淀粉凝胶中分离。分离方法已在其他地方描述过。发现所有酶的表型均符合哈迪 - 温伯格定律分布。根据在德国和中欧地区进行的其他调查结果,计算出的基因频率与文献数据吻合良好。尽管匈牙利西部的PGM2频率水平高于弗兰肯地区,但在匈牙利西部和弗兰肯地区这些酶表型的基因频率之间未发现显著差异。