Simon C D, Honeyman T W, Fray J C
Am J Physiol. 1984 Jan;246(1 Pt 1):E84-8. doi: 10.1152/ajpendo.1984.246.1.E84.
The mechanisms whereby the pituitary gland maintains arterial pressure were investigated in rats. The arterial pressure in hypophysectomized rats was 30 mmHg below normal. Saralasin or captopril caused a further fall of 25 and 30 mmHg, respectively, suggesting that the renin-angiotensin system plays a role in blood pressure maintenance in hypophysectomized rats. Growth hormone administration to hypophysectomized rats increased the arterial pressure, but pretreatment with captopril prevented the effect. Plasma renin activity and basal renin secretion (in vitro) was normal in hypophysectomized rats despite a twofold greater renal renin content. Secretory responsiveness to isoproterenol and calcium omission was lower in hypophysectomized rats. It is concluded that the renin-angiotensin system plays a role in maintaining arterial blood pressure in hypophysectomized rats although the responsiveness of the system may be decreased.
在大鼠中研究了垂体维持动脉血压的机制。垂体切除大鼠的动脉血压比正常低30 mmHg。沙拉新或卡托普利分别使血压进一步下降25 mmHg和30 mmHg，这表明肾素-血管紧张素系统在垂体切除大鼠的血压维持中起作用。给垂体切除大鼠注射生长激素可使动脉血压升高，但预先用卡托普利处理可阻止这种作用。垂体切除大鼠的血浆肾素活性和基础肾素分泌（体外）正常，尽管肾脏肾素含量增加了两倍。垂体切除大鼠对异丙肾上腺素和钙缺失的分泌反应性较低。结论是，肾素-血管紧张素系统在垂体切除大鼠的动脉血压维持中起作用，尽管该系统的反应性可能降低。
