Kanitakis J, Perrot H, Schmitt D, Viac J, Hermier C, Thivolet J
Ann Dermatol Venereol. 1983;110(12):993-1000.
We report a new case of a clear-cell acanthoma with an unusual location (para-anal), which was studied by electronmicroscopic and immuno-histological methods, using monoclonal antibodies. The results of this study showed that: a) the inflammatory cellular infiltrate comprised a small number of T-suppressor/cytotoxic lymphocytes and a small number of Langerhans cells, b) Langerhans cells were present in the affected epidermis in reduced numbers (2.2 p. 100) when compared to normal epidermis (4-6 p. 100), c) there was a disorder of both keratinization and epidermal differentiation as was shown by the abnormal reactivity of the tumor to monoclonal antibodies KL1 and BL7, d) human papilloma viruses do not seem to be involved in the genesis of the tumour, e) tumoral cells did not show (secretory) eccrine differentiation, f) the pemphigus antigen was present in the intercellular space of the affected epidermis.
我们报告了一例位于不寻常部位（肛门旁）的透明细胞棘皮瘤新病例，采用单克隆抗体，通过电子显微镜和免疫组织学方法对其进行了研究。本研究结果显示：a）炎性细胞浸润包括少量抑制性/细胞毒性T淋巴细胞和少量朗格汉斯细胞；b）与正常表皮（每100个中有4 - 6个）相比，病变表皮中的朗格汉斯细胞数量减少（每100个中有2.2个）；c）肿瘤对单克隆抗体KL1和BL7反应异常，表明存在角化和表皮分化紊乱；d）人乳头瘤病毒似乎未参与肿瘤的发生；e）肿瘤细胞未显示（分泌性）小汗腺分化；f）天疱疮抗原存在于病变表皮的细胞间隙中。
