Siler-Khodr T M, Kuehl T J, Vickery B H
Fertil Steril. 1984 Mar;41(3):448-54. doi: 10.1016/s0015-0282(16)47726-5.
In order to study the function of a gonadotropin-releasing hormone (GnRH) in pregnancy, a GnRH antagonist was administered to pregnant baboons (35 to 45 days' gestation) over 7 days. A marked suppression of progesterone, estrone, and estradiol was observed during treatment. In two animals, estrogens were still suppressed later in pregnancy (days 95 to 116), and delivery resulted in stillbirths. In one of these animals the placenta was recovered, and it was half normal size. In the third animal, the circulating steroids, including the estrogens, returned to normal levels following antagonist administration, and a small live-born fetus was delivered. These data indicate that interference with GnRH activity during early pregnancy can result in stillbirths, possibly due to induction of placental insufficiency. Thus, these studies support the hypothesis that chorionic GnRH has a physiologic function during pregnancy in the control of placental hormonogenesis and normal fetal outcome.
为了研究促性腺激素释放激素（GnRH）在妊娠中的作用，在7天内给妊娠35至45天的狒狒注射GnRH拮抗剂。治疗期间观察到孕酮、雌酮和雌二醇显著抑制。在两只动物中，妊娠后期（95至116天）雌激素仍被抑制，分娩导致死产。在其中一只动物中回收了胎盘，其大小只有正常的一半。在第三只动物中，给予拮抗剂后，包括雌激素在内的循环类固醇恢复到正常水平，并分娩出一个存活的小胎儿。这些数据表明，妊娠早期干扰GnRH活性可能导致死产，这可能是由于胎盘功能不全所致。因此，这些研究支持了绒毛膜GnRH在妊娠期间对胎盘激素生成和正常胎儿结局控制具有生理功能这一假说。
