抗厌氧药物对小鼠脆弱拟杆菌实验性感染影响的定量研究。

Quantification of the effect of anti-anaerobic drugs in experimental Bacteroides fragilis infection in mice.

作者信息

Dijkmans B A, Mattie H, Hermans J, van Furth R

出版信息

J Antimicrob Chemother. 1984 Jan;13(1):79-86. doi: 10.1093/jac/13.1.79.

DOI:10.1093/jac/13.1.79

Abstract

As a basis for the quantitation of the effect of anti-anaerobic drugs in vivo, an experimental thigh infection in mice was developed in which co-inoculation of Bacteroides fragilis and Escherichia coli is obligatory for proliferation of Bact. fragilis. The inhibitory effect of metronidazole and tinidazole on the proliferation of Bact. fragilis was assessed in this model. Both metronidazole and tinidazole showed a significant dose-effect relationship with respect to the outgrowth of Bact. fragilis but not that of E. coli. The effect of both drugs on Bact. fragilis was similar and at all dosage levels a significant correlation was found between the numbers of Bact. fragilis and E. coli.

摘要

作为体内抗厌氧菌药物效果定量的基础，建立了小鼠大腿感染实验模型，其中脆弱拟杆菌的增殖需要与大肠杆菌共同接种。在此模型中评估了甲硝唑和替硝唑对脆弱拟杆菌增殖的抑制作用。甲硝唑和替硝唑对脆弱拟杆菌的生长均呈现显著的剂量效应关系，但对大肠杆菌的生长无此关系。两种药物对脆弱拟杆菌的作用相似，且在所有剂量水平下，脆弱拟杆菌和大肠杆菌的数量之间均存在显著相关性。

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