Acute disseminated histiocytosis-X: in situ immunophenotyping with monoclonal antibodies.
作者信息
Bos J D, Sillevis Smitt J H, Krieg S R, Bakker P M, Vos G D, van Zaane D J
出版信息
J Cutan Pathol. 1984 Feb;11(1):59-64. doi: 10.1111/j.1600-0560.1984.tb00350.x.
Abstract
The proliferating skin cells in a case of acute disseminated histiocytosis-X (Abt-Letterer-Siwe disease) confirmed by electron microscopy, were characterized by a panel of monoclonal antibodies using an immunoperoxidase technique. The "histiocytes" were found to stain with OKT-6 (anti-T6) and anti-HLA-DR antibodies. Unexpectedly, slight staining was also observed with Leu 3a (anti-T4) and OKM-1. A proliferative process of T4, T6, HLA-DR, OKM-1 positive Langerhans' cells has not yet been described and may be specific for histiocytosis-X.
摘要
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