Harley H, Alp M H
Med J Aust. 1983;2(12):627-8.
Fifty-eight patients with chronic duodenal ulceration proven at endoscopy consented to enter a trial comparing the effect of colloidal bismuth subcitrate (CBS)tablets with that of cimetidine. Fifty-four patients completed the six-week trial. An endoscopic assessment of healing was made at four weeks. If healing had not occurred, the trial was continued for another two weeks and the endoscopy was repeated. At four weeks, healing at endoscopy was demonstrated in 82% of patients receiving CBS and in 58% of those receiving cimetidine. At six weeks, the healing rates were 93% and 81%, respectively. No side effects were noted in either group. Continued smoking was not found to have an adverse effect on the healing rate of ulcers in either treatment group.
58例经内镜检查证实患有慢性十二指肠溃疡的患者同意参加一项试验，比较枸橼酸铋钾（CBS）片与西咪替丁的疗效。54例患者完成了为期六周的试验。在四周时进行了内镜愈合评估。如果未出现愈合，试验再持续两周并重复内镜检查。四周时，接受CBS治疗的患者中82%在内镜检查中显示愈合，接受西咪替丁治疗的患者中这一比例为58%。六周时，愈合率分别为93%和81%。两组均未观察到副作用。在任何一个治疗组中，持续吸烟均未被发现对溃疡愈合率有不利影响。
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