Boonyapisit S, Manatsathit S, Kachintorn U, Tanwandee T, Sattawatthamrong Y, Chinapak O
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1994 Nov;77(11):566-71.
104 duodenal ulcer patients were classified into non-smokers (76) and smokers (28). Their age range was between 14-72 years. They were randomly treated with cimetidine (28 non-smokers and 8 smokers), colloidal bismuth (27 non-smokers and 10 smokers) and sucralfate (21 non-smokers and 10 smokers). Follow-up endoscopic examination at 4, 6 and 8 weeks showed that overall healing rates were better in the non-smokers than in the smokers (64.5% against 46.4% at 4 weeks and 92.1% against 67.8% at 6 weeks) and almost all ulcers had healed at the end of 8 weeks (100% in non-smokers and 96.4% in smokers). Among non-smokers, there were no statistically significant differences in the healing rates by any medication at any period of time. Among smokers, colloidal bismuth had significant better healing rate at 6 weeks over cimetidine and sucralfate. (p = 0.04 and p = 0.041 respectively). Overall relapse rates were higher among smokers (32.1%) than non-smokers (10.5%). Of the 3 medications, sucralfate had the lowest relapse rate in both smokers (20%) and non-smokers (9.5%), while colloidal bismuth had the highest relapse rates (40% for smokers and 11.1% for non-smokers).
104例十二指肠溃疡患者被分为非吸烟者（76例）和吸烟者（28例）。他们的年龄在14至72岁之间。他们被随机给予西咪替丁（28例非吸烟者和8例吸烟者）、胶体铋（27例非吸烟者和10例吸烟者）和硫糖铝（21例非吸烟者和10例吸烟者）进行治疗。在4周、6周和8周进行的随访内镜检查显示，非吸烟者的总体愈合率高于吸烟者（4周时分别为64.5%和46.4%，6周时分别为92.1%和67.8%），并且几乎所有溃疡在8周结束时都已愈合（非吸烟者为100%，吸烟者为96.4%）。在非吸烟者中，任何药物在任何时间段的愈合率均无统计学显著差异。在吸烟者中，胶体铋在6周时的愈合率显著高于西咪替丁和硫糖铝（分别为p = 0.04和p = 0.041）。吸烟者的总体复发率高于非吸烟者（32.1%对10.5%）。在这三种药物中，硫糖铝在吸烟者（20%）和非吸烟者（9.5%）中的复发率最低，而胶体铋的复发率最高（吸烟者为40%，非吸烟者为11.1%）。
