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[胃肠道疾病患者术后血液中激素浓度及血液吸附的影响]

[Concentration of hormones in the blood of patients with diseases of the gastrointestinal tract in the postoperative period and the effect of hemosorption].

作者信息

Bobkov A I, Semavin I E, Muratov N F, Semenova V V, Pospelov V V

出版信息

Vopr Med Khim. 1983 Nov-Dec;29(6):39-44.

PMID:6367209
Abstract

Concentrations of cortisol, renin, insulin, thyrocalcitonin were increased and those of triiodothyronine and testosterone were decreased within 1-2 days of a postoperative period. The degree of impairment of content of the hormones correlated with severity of the disease (the most distinct alterations were noted in fatal outcome). Normalization of the hormonal patterns within the first week indicated the favourable course of the disease. In generalized pyoperitoneum a number of hormones wer eliminated from blood after haemosorption: cortisol, aldosterone, triiodothyronine, dehydroepiandrosterone, insulin, thyrotropic hormone, testosterone. The content of adrenal gland hormones was rapidly restored. Other hormones (insulin, thyrotropic hormone, testosterone) apparently had to be administered in the course of therapy. Increases in renin activity, in content of blood somatotropin and thyrocalcitonin appear to be adaptive reactions in response to elimination during haemosorption of a number of biologically active substances.

摘要

术后1 - 2天内,皮质醇、肾素、胰岛素、甲状腺降钙素浓度升高,而三碘甲状腺原氨酸和睾酮浓度降低。激素含量的受损程度与疾病严重程度相关(在致命结局中观察到最明显的变化)。第一周内激素模式的正常化表明疾病进程良好。在弥漫性脓性腹膜炎中,血液吸附后血液中一些激素被清除:皮质醇、醛固酮、三碘甲状腺原氨酸、脱氢表雄酮、胰岛素、促甲状腺激素、睾酮。肾上腺激素含量迅速恢复。其他激素(胰岛素、促甲状腺激素、睾酮)显然必须在治疗过程中进行补充。肾素活性增加、血液中生长激素和甲状腺降钙素含量增加似乎是对血液吸附过程中多种生物活性物质清除的适应性反应。

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