Klein R, Klein B E, Moss S E, Davis M D, DeMets D L
Arch Ophthalmol. 1984 Apr;102(4):520-6. doi: 10.1001/archopht.1984.01040030398010.
In a population-based study in southern Wisconsin, 996 insulin-taking, younger-onset diabetic persons were examined using standard protocols to determine the prevalence and severity of diabetic retinopathy and associated risk variables. The prevalence of diabetic retinopathy varied from 17% to 97.5% in persons with diabetes for less than five years and 15 or more years, respectively. Proliferative retinopathy varied from 1.2% to 67% in persons with diabetes for less than ten years and 35 or more years, respectively. For persons with diabetes of 10 years' duration or less, the Cox regression model relates the severity or retinopathy to longer duration, older age at examination, and higher levels of glycosylated hemoglobin. After ten years of diabetes, severity of retinopathy was related to longer duration, high levels of glycosylated hemoglobin, presence of proteinuria, higher diastolic BP, and male sex.
在威斯康星州南部一项基于人群的研究中，对996名服用胰岛素的早发型糖尿病患者采用标准方案进行检查，以确定糖尿病视网膜病变的患病率、严重程度及相关风险变量。糖尿病病程小于5年和15年及以上的糖尿病患者中，糖尿病视网膜病变的患病率分别为17%至97.5%。增殖性视网膜病变在糖尿病病程小于10年和35年及以上的患者中分别为1.2%至67%。对于糖尿病病程为10年及以下的患者，Cox回归模型显示视网膜病变的严重程度与病程延长、检查时年龄较大以及糖化血红蛋白水平较高有关。糖尿病病程达10年后，则视网膜病变的严重程度与病程延长、糖化血红蛋白水平高、蛋白尿的存在、舒张压较高以及男性性别有关。
