Wieringa T, Bos M P, van Putten J P, Krans H M
Biochim Biophys Acta. 1984 Mar 23;803(3):129-36. doi: 10.1016/0167-4889(84)90002-8.
The effects of adrenaline and 8-bromo-cAMP on 2-deoxyglucose uptake in isolated rat adipocytes were investigated under conditions of unidirectional flux, in which the transport process is rate limiting. Adrenaline showed a dualistic effect in the absence of insulin. At concentrations below 1 microM adrenaline stimulated 2-deoxyglucose uptake; at higher concentrations adrenaline inhibited the uptake. In the presence of insulin at the maximum effective concentration, addition of adrenaline further increased the 2-deoxyglucose uptake by about 50%. In the presence of insulin 8-bromo-cAMP had the same effect as adrenaline. In the absence of insulin, 8-bromo-cAMP only inhibited 2-deoxyglucose uptake.
在单向通量条件下研究了肾上腺素和8-溴环磷腺苷（8-bromo-cAMP）对分离的大鼠脂肪细胞摄取2-脱氧葡萄糖的影响，在这种条件下转运过程是限速的。在没有胰岛素的情况下，肾上腺素表现出二元效应。在浓度低于1微摩尔时，肾上腺素刺激2-脱氧葡萄糖摄取；在较高浓度时，肾上腺素抑制摄取。在存在最大有效浓度胰岛素的情况下，添加肾上腺素可使2-脱氧葡萄糖摄取进一步增加约50%。在存在胰岛素的情况下，8-溴环磷腺苷与肾上腺素具有相同的作用。在没有胰岛素的情况下，8-溴环磷腺苷仅抑制2-脱氧葡萄糖摄取。
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