男性急性淋菌性尿道炎合并沙眼衣原体感染的治疗
Treatment of acute gonococcal urethritis in men with simultaneous infection with Chlamydia trachomatis.
作者信息
Csángó P A, Salveson A, Gundersen T, Jagars G, Bjerk O
出版信息
Br J Vener Dis. 1984 Apr;60(2):95-8. doi: 10.1136/sti.60.2.95.
Each of 201 men with symptoms and signs of acute urethritis was randomly assigned to one of two treatment regimens: ampicillin (2g) plus probenecid (1g), or sulphamethoxazole-trimethoprim (SMX-TMP) (sulphamethoxazole 1600 mg plus trimethoprim 320 mg) four tablets twice daily for two days. Before treatment Neisseria gonorrhoeae was isolated from 162 patients, while coexistent Chlamydia trachomatis was recovered from 42 (26%) men. After treatment N gonorrhoeae persisted in 11 (14.3%) of the 77 patients treated with ampicillin and probenecid and in three (3.5%) of the 85 treated with SMX-TMP (p less than 0.05), while C trachomatis persisted in four (16%) of the 25 men treated with SMX-TMP and in all 17 patients treated with ampicillin and probenecid. SMX-TMP was thus more effective than ampicillin in treating acute gonorrhoea in men and in eradicating concurrent C trachomatis infection.
201名有急性尿道炎症状和体征的男性被随机分为两种治疗方案之一：氨苄西林（2克）加丙磺舒（1克），或复方新诺明（SMX-TMP）（磺胺甲恶唑1600毫克加甲氧苄啶320毫克），每日两次，每次四片，共两天。治疗前，从162名患者中分离出淋病奈瑟菌，同时从42名（26%）男性中检出合并沙眼衣原体感染。治疗后，在接受氨苄西林和丙磺舒治疗的77名患者中，11名（14.3%）淋病奈瑟菌持续存在；在接受SMX-TMP治疗的85名患者中，3名（3.5%）淋病奈瑟菌持续存在（P<0.05）。而在接受SMX-TMP治疗的25名男性中，4名（16%）沙眼衣原体持续存在；在接受氨苄西林和丙磺舒治疗的所有17名患者中，沙眼衣原体均持续存在。因此，SMX-TMP在治疗男性急性淋病和根除合并沙眼衣原体感染方面比氨苄西林更有效。
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