通过人单核细胞Fc受体与IgG的不同反应性分离天然细胞毒性和抗体依赖性细胞毒性。
Separation of natural and antibody-dependent cytotoxicity by differential reactivity of human mononuclear cell Fc receptors with IgG.
作者信息
Froelich C J, Bankhurst A D
出版信息
Clin Exp Immunol. 1984 Mar;55(3):664-70.
Abstract
Nylon wood non-adherent, human peripheral blood mononuclear cells which are reactive with the OKM1 monoclonal antibody could be separated into two subpopulations based on their Fc receptor reactivity with human monomeric IgG (FcR-IgG) using flow cytometry. The majority of natural killer cells was found primarily in the OKM1+ subset with low FcR reactivity. In contrast, effector cells for antibody-dependent cytotoxicity (K cells) were found in subsets with both high and low FcR-IgG reactivity.
摘要
尼龙木非黏附性、可与OKM1单克隆抗体发生反应的人外周血单核细胞，使用流式细胞术，可根据其与人单体IgG（FcR-IgG）的Fc受体反应性分为两个亚群。发现大多数自然杀伤细胞主要存在于FcR反应性低的OKM1+亚群中。相反，抗体依赖性细胞毒性的效应细胞（K细胞）存在于FcR-IgG反应性高和低的亚群中。
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