Mori T, Nishizuka M
Acta Anat (Basel). 1978;100(4):369-74. doi: 10.1159/000144919.
In the ovariectomized mice given 10 injections of 100 micrograms 17 beta-estradiol at intervals of 2 weeks from 60 days of age, the vaginal epithelium was atrophic when killed more than 2 months after the last injection. If mice given 3 daily injections of 20 micrograms 17 beta-estradiol from the day of birth were similarly treated with estradiol after postpuberal ovariectomy, the vaginal epithelium was stratified and hyperplastic at autopsy performed more than 2 months later. These changes in the epithelium persisted for at least 30 days after transplantation of the vaginae to normal ovariectomized hosts. Neonatal treatments only did not produce such persistent vaginal changes. In view of these results, additional effects of neonatal and postpuberal injections of estrogen on the vaginal epithelium are evident. However, effects of such neonatal and postpuberal injections of estrogen might be transient on the uterine epithelium, since abnormal proliferation was not observed in it.
在60日龄时每隔2周注射10次、每次100微克17β-雌二醇的去卵巢小鼠中，在最后一次注射后2个多月处死时，阴道上皮萎缩。如果从出生日起每天注射3次、每次20微克17β-雌二醇的小鼠在青春期后去卵巢后同样用雌二醇处理，在2个多月后进行尸检时，阴道上皮分层且增生。将阴道移植到正常去卵巢宿主后，这些上皮变化持续至少30天。仅新生儿期处理未产生这种持续性的阴道变化。鉴于这些结果，新生儿期和青春期后注射雌激素对阴道上皮的额外作用是明显的。然而，这种新生儿期和青春期后注射雌激素对子宫上皮的作用可能是短暂的，因为未观察到子宫上皮异常增殖。
