Möller H J, Kissling W, Herberger B, Kuss H J
Pharmacopsychiatry. 1984 Jan;17(1):29-33. doi: 10.1055/s-2007-1017403.
Ther is some clinical evidence that neuroleptics are able to increase the therapeutic effect of antidepressive drugs. From a theoretical viewpoint this could be due to influences on pharmacokinetic or receptor sensibility. In a controlled trial on 20 endogenous depressives the advantage of a combined medication of 150 mg Chlorimipramine and 9 mg p.d. Haloperidol (given over six days) were tested. Neither during the combined medication, nor after discontinuation of haloperidol, this treatment regimen proved better clinical results. According to the literature serum levels of chlorimipramine were higher in the experimental group, not the levels of desmethyl-chlorimipramine.
有一些临床证据表明，抗精神病药物能够增强抗抑郁药物的治疗效果。从理论角度来看，这可能是由于对药代动力学或受体敏感性的影响。在一项针对20名内源性抑郁症患者的对照试验中，测试了150毫克氯米帕明与每日9毫克氟哌啶醇联合用药（持续六天）的优势。无论是在联合用药期间，还是在停用氟哌啶醇之后，这种治疗方案都没有取得更好的临床效果。根据文献，实验组中氯米帕明的血清水平较高，而去甲氯米帕明的水平并非如此。
