Lambert M
Sex Transm Dis. 1984 Jan-Mar;11(1):36-40. doi: 10.1097/00007435-198401000-00010.
In 1763 Jan Fryderyk Knolle, a Polish physician, wrote his doctoral thesis on osseous syphilis, De Ossium Carie Venerea, at the University of Leipzig, Saxony (now East Germany). Knolle described the pathology, clinical picture, and treatment of syphilis of the bones and emphasized the severity and destructiveness of bony lesions, which could occur even in the early stage of the disease. An interesting and detailed drawing showing osteomyelitis of the femur, which appears to be of syphilitic origin, was included in Knolle's dissertation. This illustration is an example of 18th century syphilologic iconography. A comparison of the clinical picture of syphilis as described by Knolle with that of the present day suggests that syphilis has become a milder disease.
1763年，波兰医生扬·弗里德里克·克诺勒在萨克森州莱比锡大学（现德国东部）撰写了关于骨梅毒的博士论文《骨的性病性龋齿》。克诺勒描述了骨梅毒的病理学、临床表现及治疗方法，并强调了骨病变的严重性和破坏性，这些病变甚至可能出现在疾病的早期阶段。克诺勒的论文中包含一幅有趣且详细的插图，展示了似乎源于梅毒的股骨骨髓炎。这幅插图是18世纪梅毒学图像学的一个范例。将克诺勒所描述的梅毒临床表现与当今的情况进行比较后发现，梅毒已成为一种症状较轻的疾病。
