McConville J H, Manzella J P
Am J Med Sci. 1984 Mar-Apr;287(2):43-5. doi: 10.1097/00000441-198403000-00011.
Three adults with gram-negative bacillary meningitis were treated with an intravenous preparation of trimethoprim and sulfamethoxazole. This therapy sterilized the cerebrospinal fluid in each case. The infections occurred as complications of neurosurgery, trauma and chronic otitis media. Serratia marcescens was the causative organism in two patients and Proteus vulgaris in the third. The infecting organism was eradicated within three to 17 days of beginning intravenous trimethoprim/sulfamethoxazole. Followup CSF cultures after completing therapy were sterile. These cases suggest intravenous trimethoprim/sulfamethoxazole may be effective treatment for some cases of gram negative bacillary meningitis.
三名患有革兰氏阴性杆菌性脑膜炎的成年人接受了静脉注射甲氧苄啶和磺胺甲恶唑制剂的治疗。该疗法使每例患者的脑脊液除菌。这些感染是神经外科手术、创伤和慢性中耳炎的并发症。两名患者的致病菌为粘质沙雷氏菌，第三名患者的致病菌为普通变形杆菌。在开始静脉注射甲氧苄啶/磺胺甲恶唑后的3至17天内，感染病菌被根除。完成治疗后的脑脊液培养结果均无菌。这些病例表明，静脉注射甲氧苄啶/磺胺甲恶唑可能是治疗某些革兰氏阴性杆菌性脑膜炎病例的有效方法。
