Brown M J, Asbury A K
Ann Neurol. 1984 Jan;15(1):2-12. doi: 10.1002/ana.410150103.
Peripheral nerve disorders are important late complications of diabetes mellitus. Polyneuropathy, which may involve varying proportions of sensory, motor, and autonomic fibers, is considered the consequence of metabolic derangements that result from chronic hyperglycemia. Symmetrical proximal motor neuropathy ("diabetic amyotrophy") also may have a metabolic basis. Mononeuropathies in diabetes may have an ischemic or compressive cause. Advances have been made in understanding the biochemical basis for diabetic polyneuropathy. The treatment of symptomatic diabetic neuropathy should be directed toward long-term normalization of blood glucose until more specific therapies become available.
周围神经疾病是糖尿病重要的晚期并发症。多发性神经病可能累及不同比例的感觉、运动和自主神经纤维，被认为是慢性高血糖导致的代谢紊乱的结果。对称性近端运动神经病（“糖尿病性肌萎缩”）也可能有代谢基础。糖尿病中的单神经病可能有缺血或受压原因。在理解糖尿病性多发性神经病的生化基础方面已经取得了进展。有症状的糖尿病神经病变的治疗应旨在使血糖长期正常化，直到有更具体的治疗方法可用。
